Changing feeds or feeding straight grains will unbalance a deer’s digestive system, and do more harm than good when it comes to attracting and growing tag-worthy deer.
It is now clear that human neoplasms form, progress, and respond to therapy in the context of an intimate crosstalk with the host immune system.
For a long time, tumors were considered as highly homogenous entities resulting from the clonal expansion of a single cell with specific genetic or epigenetic defects (1).
Now, it is clear that both hematopoietic and solid neoplasms are highly heterogenous, not only because malignant cells with distinct phenotypic and behavioral features generally co-exist, but also because multiple non-transformed cells are co-opted by growing cancers to support their needs.
Mechanistically, immunogenic cell death (ICD) relies on the pre-mortem activation of several stress response pathways that are associated with the emission of a well-defined set of danger signals by dying cancer cells (24–26).