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Similarly, the magnitude of increased optical density above baseline at 450 nm (delta OD 450) by amniotic fluid spectrophotometric measurement is used to predict the severity of fetal hemolytic disease in pregnancies complicated by rhesus isoimmunization.

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Timed ovulation, either by basal body temperature recording or semiquantitative assessment of luteinizing hormone surge, predicts gestational age within ±4 to 6 days.

Ovulation induction with agents such as clomiphene citrate and Pergonal, also accurately predicts gestational age.

The sac is measured inside the hyperechoic rim, including only the echo-free space (Fig. The gestational sac is imaged first in the longitudinal plane, obtaining long axis and anteroposterior measurements perpendicular to each other. The longitudinal diameter is measured between the small crosses (1) and the anteroposterior diameter is measured between the larger crosses (2). Transverse image obtained at the level of the anteroposterior diameter.

Then, in the transverse plane at the level of the anteroposterior measurement, the width measurement is obtained. The transverse diameter is measured between the crosses.

Both parameters are useful because each measures a different aspect of the first-trimester pregnancy and may be used at different times during the first trimester.

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